Modus Tablets

What Is Modus Tablet?

Progestin is a hormone produced by the ovary in the post ovulatory half of the menstrual cycle. The term Progestin by itself means that which favors pregnancy. From this its most basic function is derived, in that, progestin is a substance that converts the estrogen primed womb (endometrium) into a secretory state to promote the continuation of pregnancy should it occur.
The secretory or soggy endometrium is also able to shed easily in the absence of a gestation. Progestins have been synthesized artificially since the 1950's; they have undergone numerous advancements through generations and today we have the fourth generation in vogue.
Modus tablet is an example of one such synthetic progestin - Medroxyprogesterone. Albeit a first generation type, Modus still finds useful applicability in many disorders of women's health ranging from dysfunctional uterine bleeding to hormonal therapy in cancer.
We also have in stock Depot Provera Contraceptive Injection which also has Medroxyprogesterone Acetate (MPA) as its active ingredient and is used as a contraceptive as well as for other indications.

Marketing and Active Ingredients of Modus 10mg Tablets

Modus 10mg tablets are marketed by GlaxoSmithKline Pharmaceuticals and contains the formulated salt of the first generation progestin Medroxyprogesterone.

Formulation and Active Ingredients of Modus Tablets

Medroxyprogesterone Acetate (MPA) is the active ingredient of Modus. Modus tablets are sold in blister packs of ten tablets with two different dosage strengths the 2.5mg and the 10mg.

Manufacturer of Modus Tablets

GlaxoSmithKline Pharmaceuticals
Website: www.gsk-india.com

How do Modus tablets work? – Pharmacodynamics and Mechanisms of Clinical Actions of Modus

Although Progestins are used most commonly as part of the oral contraceptive pill, Medroxyprogesterone in its oral form is not generally available for this purpose as better potent and newer progestin agents are preferred instead. Progesterone finds various actions in the female genital apparatus. It causes mammary gland proliferation to prepare the breast for lactation.
In the cervix, watery cervical secretions are made viscid and impenetrable to sperm entry. A subsidiary contraceptive action of synthetic progestins used in pills.
Above all, in the uterus, Progesterone brings about secretory changes in a previously estrogen primed endometrium by increased blood flow, gland tortuosity and secretions from them.
Removal of progesterone results in the shedding of such a secretory endometrium (womb lining) resulting in menses. In the same lines, artificial menses also termed "withdrawal bleeding" occurs when an exogenously administered progestin like Modus is given for a period of time say from five to fifteen days and then stopped.
With prolonged exposure to continuous progesterone as with long term injectable preparations of Medroxyprogesterone, the womb lining gets soggy or spongy (decidualized) and is highly unfavorable to the implantation of any pregnancy, where from comes the contraceptive benefit of such a depot formulation.
LH & FSH are two brain based hormones that are tightly controlled in a coordinated hormonal feedback loop of action with ovarian estrogen/progestin. When Medroxyprogesterone is used either as a tablet or as an injectable, it suppresses LH/FSH severely which in turn blocks ovarian estrogen production. This effect becomes more pronounced with time, reaching near menopausal effects with total loss of endogenous estrogen. Such a state is vital in managing cancers that are dependent on endogenous estrogens such as tumors of the breast, uterus and kidney among others.

Modus Dosage – Modalities and Instructions

The dose of modus depends upon or varies with the clinical situation it is used in. In dysfunctional uterine bleeding, anywhere from 2.5 to 5 or even 10 mg a day, in single or divided doses is used in the latter half of the menstrual cycle.
In HRT or Hormone Replacement Therapy, 2.5mg daily is used in the latter half of the cycle.
In Cancer prophylaxis or palliative treatments, higher doses are employed, and these are in the ranges from 300 mg to even 1.5 grams per day depending upon the type of tissue. Higher strength formulations of 100mg per tab from different brands such as Deviry are available.

Clinical Applications, Uses and Indications of Modus Tablets

Dysfunctional Uterine Bleeding:
Modus is used in the second half of the ovulatory cycle. This phase is called as the luteal phase and many women are deficient in progestin levels in this phase, leading to improper menstrual cycles or flow. Used from day 16 to day 25 of the cycle serves to correct dysfunctional cycles. Menorrhagia or heavy periods also benefit from such treatment especially if given in such a manner, cyclically over three to six months. The presence of estrogens in the first half of the cycle makes the treatment more efficient in reducing menstrual pains and quantum of flow, thereby relieving dysmenorrhea and Iron deficiency anemia (from the excessive blood loss).
Secondary Amenorrhoea:
It is the absence of periods for six months or more in a woman who has otherwise menstruated regularly and is not in the vicinity of menopause. Such a condition can arise from various causes ranging from stress, anorexia and over exercising to thyroid or pituitary problems. Elicitation of the cause is foremost but once this is done, Modus plays the important role of restoring a period in such women in the form of a withdrawal bleed.
HRT (Hormone Replacement Therapy):
In women with an intact uterus, the presence of Modus in the latter half of the cycle in combination with low dose estrogens used in the first half is absolutely essential as part of Hormone replacement therapy. The reason being Modus prevents the excessive and unopposed stimulation of the womb endometrium preventing malignant changes.
PCOS (Polycystic Ovary Syndrome):
This is a disorder that is fairly common in the present day. It is characterized by a gamut of signs and symptoms, prominent among which are Anovulation, Oligomenorrhoea and Infertility. Women who suffer from Polycystic Ovaries benefit from resetting to a state of regular periods and suppression of their androgen levels. Modus helps in restoring periods in these women as well as preventing the unregulated thickening of the womb lining in such cases.
Endometriosis:
This is a condition caused by the presence of ectopic endometrium outside the uterus anywhere in the pelvic tissues. It is dominated by problems of painful periods (dysmenorrhea) and Infertility. Continuous administration of Modus /Progestins can create a state of near total menopause or artificially induced gonadal atrophy which suppresses endogenous estrogen production indirectly through suppression of the central gonadotropins (LH/FSH). Modus is one modality of treatment in the array of agents available to combat endometriosis.
Endometrial Hyperplasia:
This is a premalignant lesion of the womb lining or endometrium and Modus forms a successful modality of medical management in simple hyperplasia of the endometrium. Modus given from 10 to 20 mg per day or cyclical 12 to 14 days a month is beneficial in reversing this condition in a number of women. Although Mirena and Megestrol are better alternatives in complex or atypical hyperplasia.
Cancer Treatment:
Modus is used as part of the hormonal treatment of PR + ve (Progesterone receptor expressive) Breast Cancer. MPA may be used albeit in much higher doses for the palliative treatment of late stage endometrial, prostatic and renal cancers.

Side Effects of Modus Tablets

The possible side effects of Modus tablets are temporary and often easily managed. The side effects of Medroxyprogesterone vary greatly with the dose and the form they are used with.
Injectable depot preparation (Depot Provera) and higher doses used in cancer management protocols have higher chance of adverse reactions than Modus used in 2.5 or 10mg doses for short periods for dysfunctional uterine bleeding or secondary amenorrhoea.

• Irregular intermittent spotting while on therapy, termed as "breakthrough bleeding".
• Tendency to temporary Infertility on prolonged usage is noted.
• Acne, Hirsutism, Alopecia
• Rash, Urticaria
• Nausea, vomiting, Diarrhea
• Muscle pains or cramps
• Breast engorgement/fullness, Pelvic infections, and cervical erosions.
• Palpitations, Hypertension, Thrombosis, Myocardial Infarction, Stroke.

Adverse Reactions and Disadvantages of Modus Tablets

Teratogenicity in the form of webbed toes and fingers, masculinization of female infant genitalia and Low birth weight babies are reported in women who take Modus while they are unaware of, or not investigated for pregnancy.
Progestins promote fluid retention and weight gain and Modus is no exception. The amount of weight gained is mostly proportional to the duration of therapy.
Increased glucose intolerance and raised blood sugars are known.
Breast cancer may be a possibility when used for long periods of time of more than 2 years especially when used by younger women in the 25 -35 age group.

Interactions and Interference with Modus Treatment

Important medicines that reduce the effectiveness of Modus include the following:
Drugs like aminogluthetimide, griseofulvin, rifampin, phenobarbital, phenytoin and carbamazepine are known enzyme inducers which will reduce the efficacy of MPA. Caution when used for contraception is advised with these agents.
Plasma gonadotropin assays, urinary steroid assays and coagulation profiles may be deranged while on MPA.

Contraindications And Precautions With The Use Of Modus

Modus must not be used in the following situations and care should be taken where advised to obtain medical consultation in any of these scenarios:

• Allergic or hypersensitive to MPA (Medroxyprogesterone Acetate)
• Suspected pregnancy, undiagnosed vaginal bleeding, irregular periods/unsure dates.
• Suspicious breast lumps, high risk for breast cancer, diagnosed breast cancer.
• High risk for blood clotting disorders, thrombotic events, thromboembolism, stroke, uncontrolled high blood pressure etc.
• Preexisting medical conditions such as epilepsy, seizures and migraine warrant medical advice prior to taking Modus.
• Chronic Liver or Kidney or Adrenal disease.
• A Pap smear and or colposcopy is advisable in women with cervical lesions or high risk factors for cervical cancer or intra epithelial neoplasia.

Buy Modus Tablets Online For Only $0.36 a pill

You can buy Modus tablets online from allcontraceptives.com. Modus pills are available for only $0.36 a pill when you place an oder for 300 tablets.

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