Premarin Vaginal Cream

Premarin Vaginal Cream (Conjugated Estrogens Cream) - Product Information

Premarin Vaginal Cream (Conjugated Estrogens Cream) contains a mixture of Estrogen hormones. Premarin Vaginal cream is used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

These symptoms are caused by the body making less Estrogen (Estrogen is a female sex hormone produced by the ovaries) and Premarin Vaginal Cream can relieve the sysmptoms by replacing the Estrogen that the body no longer produces.

Premarin Vaginal cream must not be used to prevent heart disease or dementia, because this medicine may actually increase your risk of developing these conditions.

We also have in stock Estriol Tablets (Evalon Pills) which are prescribed as Hormone replacement therapy (HRT) for several menopausal symptoms such as Atrophy of the lower urogenital tract, management of micturition complaints, hot flushes and night sweating.

Presentation and Marketing of Premarin Vaginal Cream

Premarin Vaginal Cream is manufactured by Pfizer Canada Inc and is offered to the consumer in a 14 gm tube.

Manufacturer of Premarin Vaginal Cream

Manufactured in Canada by Pfizer Canada Inc. 
Website: www.pfizer.com

Active Ingredients present in Premarin Vaginal Cream

The active ingredients present in Premarin Vaginal Cream are Conjugated Estrogens. Each gram of the cream contains 0.625 mg of Conjugated Estrogens

Uses of Premarin Vaginal Cream (Conjugated Estrogens Cream)

Premarin Vaginal Cream (Conjugated Estrogens) is a vaginal cream which is used for treatment of vaginal dryness, burning and painful sexual intercourse.

Estrogen is one of the main hormones responsible for helping to keep many of the tissues in a woman's body healthy, such as the tissues of the urinary system and the lining of the vagina. During the menopause, the level of the estrogen in a woman's body will decrease.

By replacing the estrogen that a woman's body no longer makes, Premarin Vaginal Cream can relieve some of the symptoms that a woman may experience at the time of menopause, such as vaginal itching and dryness.

How Does Premarin Vaginal Cream Work?

Conjugated Estrogens like those present in Premarin Vaginal Cream are water-soluble and are well-absorbed through the skin, mucous membranes, and the gastrointestinal (GI) tract. Exogenous Estrogens are metabolized in the same process as endogenous estrogens. Circulating estrogens exist in a dynamic equilibrium of metabolic interconversions. These transformations take place mostly in the liver. Estradiol is converted reversibly to estrone, and both can be converted to Estriol, which is a major urinary metabolite.

In postmenopausal women, a significant portion of the circulating estrogens exists as sulfate conjugates, specially Estrone Sulfate, which serves as a circulating reservoir for the formation of more active Estrogens.

Premarin Vaginal Cream (Conjugated Estrogens) Dosage

The recommended dosage of Premarin Vaginal Cream (Conjugated Estrogens) to treat moderate to severe painful intercourse, a symptom of vulvar and vaginal atrophy (VVA) due to menopause, is given below

Cyclic administration of Conjugated Estrogens Cream 0.5 g to 2 g intravaginally daily for 21 days then off for 7 days for treatment of Atrophic Vaginitis and Kraurosis Vulvae
Cyclic administration of 0.5 g cream intravaginally daily for 21 days then off for 7 days for treatment of Moderate to Severe Dyspareunia, a Symptom of Vulvar and Vaginal Atrophy, due to Menopause
Twice-weekly administration of 0.5 g cream intravaginally (for example, Monday and Thursday) for treatment of Moderate to Severe Dyspareunia, a Symptom of Vulvar and Vaginal Atrophy, due to Menopause

Premarin Vaginal Cream - Missed Dose Instructions

In case you forget to administer Conjugated Estrogens cream, do so as soon as you remember, then go on as per your regular schedule. In case more than one dose has been missed, apply the cream on the day that you remember and continue as per your normal schedule. Do not use double your usual dose to make up for the missed application of the vaginal cream.

Premarin Vaginal Cream Overdosage

Premarin Vaginal Cream Overdosage can cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of Estrogen overdose consists of discontinuation of Premarin Vaginal Cream (Conjugated Estrogens) therapy with institution of appropriate symptomatic care.

Premarin Vaginal Cream Storage

Store Premarin Vaginal Cream at controlled room temperature (68°F to 77°F, 20°C to 25°C). Excursions are permitted to 15°C to 30°C (59°F to 86°F). Protect from light and keep away from moisture and heat.

Side Effects of Premarin Vaginal Cream

Premarin Vaginal Cream side effects with an incidence rate of 2 percent or greater are are headache, pelvic pain, vasodilation, breast pain, leucorrhea, metrorrhagia, vaginitis, vulvovaginal disorder.

Premarin Vaginal Cream Contraindications

Premarin Vaginal Cream is contraindicated in patients with a hypersensitivity to Conjugated Estrogens or any inactive ingredient present in Premarin Vaginal Cream. Premarin Vaginal Cream ia also contraindicated in the following cases:

• Undiagnosed abnormal genital bleeding
• Known, suspected, or history of breast cancer
• Known or suspected estrogen-dependent neoplasia
• Active Deep vein thrombosis (DVT), Pulmonary Embolism (PE), or a history of these conditions
• Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
• Known anaphylactic reaction or angioedema to Premarin Vaginal Cream
• Known liver dysfunction or disease
• Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders
• Known or suspected pregnancy

Interactions of Premarin Vaginal Cream with Other Drugs

Studies have shown that Estrogens are metabolized partially by cytochrome P450 3A4 (CYP3A4). Therefore, inducers or inhibitors of CYP3A4 can affect estrogen drug metabolism. Inducers of CYP3A4, such as St. John's wort (Hypericum perforatum) preparations, Phenobarbital, Carbamazepine, And Rifampin, could reduce plasma concentrations of estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. Inhibitors of CYP3A4, such as Erythromycin, Clarithromycin, Ketoconazole, Itraconazole, Ritonavir and grapefruit juice, may increase plasma concentrations of estrogens and can result in side effects.

Warnings and Precautions while Using Premarin Vaginal Cream

The warnings and precautions to be taken while undergoing therapy with Premarin Vaginal Cream are given below:
 

• Stop using Conjugated Estrogens cream if severe hypercalcemia, loss of vision, severe hypertriglyceridemia or cholestatic jaundice occurs
• Monitor thyroid function in women on thyroid replacement therapy
• An increased risk of stroke and deep vein thrombosis (DVT) has been reported with estrogen alone therapy.
• An increased risk of Endometrial cancer has been reported with the use of unopposed Estrogen therapy in women with a uterus.
• The reported endometrial cancer risk among unopposed Estrogen users is about 2 to 12 times greater than in non-users, and appears dependent on duration of treatment and on estrogen dose. Most studies show no significant increased risk associated with use of estrogens for less than 1 year.
• The relative risk of probable dementia for Conjugated Estrogens (CE 0.625 mg) alone versus placebo was 1.49

Premarin Vaginal Cream During Pregnancy

Premarin Vaginal Cream has been classified by the US FDA as Pregnancy Category X. Premarin Vaginal Cream should not be used during pregnancy. There however appears to be little or no increased risk of birth defects in children born to women who have used estrogens and progestins as an oral contraceptive inadvertently during early pregnancy.

Nursing Considerations

Premarin Vaginal Cream should not be used during lactation. Estrogen administration to nursing women has been shown to lower the quantity and quality of the breast milk. Detectable amounts of Estrogens have been found in the breast milk of women receiving treatment with Estrogen. Caution must be taken when Premarin Vaginal Cream is administered to a nursing woman.
Do not use this medicine without telling your doctor if you are breast-feeding a baby.

Buy Conjugated Estrogen Cream (Premarin Vaginal Cream) Online at Only $26.29 per Tube

You can buy Premarin Vaginal Cream online from Clear Sky Pharmacy at a cheap price. Premarin Vaginal Cream is available in strength of 0.625 mg Conjugated Estrogens, manufactured by Pfizer Limited, India is supplied in a tube of 14 gm. The cost of Conjugated Estrogens cream is only $26.29 for a 14 grams tube when you place an order for 10 tubes.

Disclaimer

The above information is provided to the best of our knowledge and in good faith, it is without a warrant of any kind, expressed or implied.

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